Pancreatic exocrine insufficiency (PEI) in paed & adults often associated w/ cystic fibrosis, chronic pancreatitis, pancreatic surgery & cancer, gastrectomy, GI bypass surgery (eg, Billroth II gastroenterostomy), ductal obstruction of pancreas or common bile duct (eg, from neoplasm), Shwachman-Diamond syndrome, status after an attack of acute pancreatitis & initiation of enteral or oral feeding. Creon 10000: Improvement of digestion & relief of maldigestion symptoms after consumption of fatty meal eg, sensation of heaviness, bloating, abdominal distension & pain/cramping, &/or diarrhoea.
Should be taken with food: Take during or immediately after meals. Swallow whole w/ sufficient
amount of fluid, do not chew/crush. For patients w/ swallowing difficulty, cap may be carefully opened
& contents may be added to an acidic soft food (eg, applesauce/yogurt)
or liqd (eg, apple/orange/pineapple). Consume mixt immediately.
Assess unusual or changes in abdominal symptoms to exclude possibility of fibrosing colonopathy, especially if taking >10,000 lipase IU/kg/day. Pregnancy.
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